Good news! Scientists identify potential drug candidate against COVID-19

Washington: Using state-of-the-art computer simulations, scientists have identied a preexisting drug, used to treat multiple diseases, including bipolar disorders and hearing loss, that could prevent the novel coronavirus from replicating in host cells, an advance that may lead to a therapeutic solution against COVID-19.

The study, published in the journal Science Advances, assessed the molecule main protease, Mpro, of the novel coronavirus which is a key enzyme that plays a central role in its life cycle.
According to the researchers, including those from the University of Chicago in the US, Mpro facilitates the virus’ ability to make proteins from its genetic material — RNA — and enables the pathogen to replicate within the host cell.

Using their expertise in modelling biological molecules, the scientists rapidly screened thousands of existing compounds for potential use against the virus.

“By virtue of the large number of compounds considered in high throughput screens, those calculations must necessarily involve a number of simplications, and the results must then be evaluated using experiments and more rened calculations,” explained study co-author Juan de Pablo from the University of Chicago.

They found that the pharmaceutical drug that shows promise as a weapon against Mpro is Ebselen — a chemical compound with anti-viral, anti-inammatory, anti-oxidative, bactericidal, and cell-protective properties.

According to the researchers, Ebselen is used to treat multiple diseases, including bipolar disorders and hearing loss.

They said several clinical trials have proven its safety for use in humans.

In the research, de Pablo and his team developed detailed models of the enzyme and the drug, and with sophisticated supercomputer simulations they discovered that Ebselen is able to decrease Mpro’s activity in two different ways.

“In addition to binding at the catalytic site of the enzyme, Ebselen also binds strongly to a distant site, which interferes with the enzyme’s catalytic function by relying on a mechanism in which information is carried from one region of a large molecule to another region far away from it through subtle structural reorganisations,” de Pablo said.

According to the scientists, this finding is particularly important since it helps explain Ebselen’s potential ecacy as a repurposed drug, and reveals a new vulnerability in the virus that was previously not known and that could be useful in developing new therapeutic strategies against COVID-19.

While the researchers believe further studies are needed to test the drug against COVID-19, they believe the two binding sites on Mpro look promising for Ebselen to be a new drug lead.

“The main protease is one of many proteins in the virus that could be targeted with existing, repurposed drugs, and there are thousands of compounds to be considered,” de Pablo said.

“We are systematically investigating each of the proteins involved in the virus function and investigating their vulnerabilities and their responses to a wide range of drugs,” he added.

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Lugo Abraham
Lugo Abraham
1 month ago

Excellent post about this possible drug to combat Covid 19, it is very interesting and hopeful to know that it is possible to fight against this tragic disease which has devastated the world, I hope that everything will be solved soon and that this medication will be of great help, Thank you very much for sharing it!

deagw2
deagw2
1 month ago

Finally, i am waiting for that as nobody believes me why, since my immune system is weak i am afraid to leave the house for 9 months already. Cool article.

sinan
sinan
1 month ago

I just wish that this is true and we finally get to move on with our lives. Covid has changed everything for the worse and there is not an improvement in almost a year. Let this be true

Meetra
Meetra
1 month ago

It’s high time a drug is introduced. Lives have stood still and most middle income families have been affected. I can’t wait for a time when we will be free of this virus. I hope this potential drug passes the tests because we are living in fear and its just so sad.

Alexis
Alexis
1 month ago

ounds like excellent news to me. This pandemic has claimed many human lives, and the fact that a drug that can help to prevent it from spreading has already been discovered is very good for everyone. Congratulations from that group of scientists. Good job

Jill Adams
Jill Adams
1 month ago

It’s really a informative article about Covid-19, I have learnt lots of thing from this. Hope people will know more from this article, I will share and tell about this what I have learnt. Thank you so much for this wonderful and informative article.

luis
1 month ago

I hope the vaccine works because this is a very bad thing that we are living, I know that there were other pandemics but it is also affecting everything drastically.

Dennis William
Dennis William
1 month ago

This is very good news at this point,I’m from Kenya,and the Covid 19 pandemic has hit really hard,disrupting learning and costing millions of losses in job cuts and stagnation of major economic activities,not to mention the loss of lives. Finally there may be hope,a light at the end of the tunnel for us to keep clinging to mother hope! Keep up the good work scientists and researchers and all other persons working tirelessly to deliver a cure,we are praying for a breakthrough!

lampro
lampro
1 month ago

This is good news and very useful, I enjoyed reading this article really explains everything on detail about identify potential drug candidate against COVID-19. The article is very unique and effective. Great and thank you so much for this wonderful page is creative and original.

bogsway
bogsway
1 month ago

Thank God if there’s a possible vaccine for Covid-19, so that people will continue what they missed in the past during this pandemic. If that will release the world will be having a new life and new start of their dreams to continue it

Makwan dusti
Makwan dusti
1 month ago

This pandemic has really shaken the world, in almost all aspects. Economically people have lost jobs and food insecurity is on its toll. News like this bring hope to our lives. I can see some light ar the end of the dark tunnel. Let me share this article just to inspire a soul to keep haning in there. Thank you.

Suhas
Suhas
1 month ago

It’s very good news that scientist has got another breakthrough for Novel Coronavirus. Frankly speaking, I am Biotechnologist & I love this kind of research. Basically, as per the news, Scientist has identified the main molecular protein which help coronavirus to replicate & scientist are now focusing on an effective drug which acts against this protein.

Zafar
Zafar
1 month ago

The virus that causes COVID-19 is mainly transmitted through droplets generated when an infected person coughs, sneezes, or exhales. These droplets are too heavy to hang in the air, and quickly fall on floors or surfaces.
You can be infected by breathing in the virus if you are within close proximity of someone who has COVID-19, or by touching a contaminated surface and then your eyes, nose or mouth.

Abdullah
Abdullah
1 month ago

If COVID-19 is spreading in your community, stay safe by taking some simple precautions, such as physical distancing, wearing a mask, keeping rooms well ventilated, avoiding crowds, cleaning your hands, and coughing into a bent elbow or tissue. Check local advice where you live and work.

Martin
Martin
1 month ago

Technology has influenced science in our days and everything is just not normal as it was, things have been beefed up, medicine, biological processes and most importantly chemical reactions and products. I love science and it’s impact to the large society

William Johnson
William Johnson
1 month ago

I want them to discover a drug or a cure for the coronavirus as soon as possible, we have been locked up for a long time and this situation is very complicated in most of the world.
Day by day I worry because more and more people are infected where I live.

Novak
Novak
1 month ago

I hope that the new medicine against the corona will be of great importance for the head of the Earth. That it will bear fruit and save all of us.

larry aron
larry aron
1 month ago

A drug which could rectify this situation is going to be the most famous drug of all time, this COVID-19 situation has badly affected the whole world. And after reading this hopeful article now I feel little relaxed. thank you so much for sharing something that everyone would love to read.

Furry
Furry
1 month ago

Today the world is a total mess and people are starving and getting poor day by day this article gave me hope for all people around the world to get better and live the way they want like before i hope this drug is not just another business deal but really to save lifes!

sonle
sonle
1 month ago

In the current context, this is extremely good news. Many thanks to those who did this helpful. I hope they will continue their work to bring even better values.

abu talha
abu talha
1 month ago

Currently there is no specific antiviral treatment for COVID-19. People with COVID-19 receive supportive care to help relieve symptoms.

Sumit Gupta
Sumit Gupta
1 month ago

This is really a good news. I think this drug will really help to fight against COVID-19. A very informative and valuable article. I really appreciate this blog post…!!!

vikky
vikky
1 month ago

Now at this time corona case will decrease linearly in all country but some countries corona case are not decrease as compare to other countries….So this is most important and launch the vaccine as too as possible…

Srac
Srac
1 month ago

It’s pleasure news and so many people suffering via corona virus (covid 19) and it’s a great news from scientists and huts off to you scientists and doctors those are protecting people from covid 19

Rahul Pal
Rahul Pal
1 month ago

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Sebastian
Sebastian
1 month ago

Hi my name is Sebastian and iam baoring with the covid 19 in my house.The news given by yourself is really informative and helpful. Iam appreciating you for that. Thank you

Kashish kapoor
Kashish kapoor
1 month ago

Wow that’s really an amazing news. We Just need a final vaccine for this corona virus and hope so soon we will get the vaccine. Well I must say this article is really great and well explained by you…👍👍👍

SAILEN BANERJEE
SAILEN BANERJEE
1 month ago

Really great news for us, we are waiting for COVID 19 vaccine. Your news is truly legit & very informative. As your news source is very much authentic. This invention of science is really good for world. Hope they will find out a permanent solution from get rid off COVID. Thanks

Camille Oh
Camille Oh
1 month ago

Great article, finally the world has making progress in combating this pandemic. Hoping this test will be finished soon for us to go back in our lives before the pandemic.

mehboob
mehboob
1 month ago

we all know that cove19 is life threatening pandemic because of which many people have died and as soon world is getting closer to the vaccine that is a good sign of life returning to the normal which existed in pre covd19 conditions,, hope the researchers will come with good news and a vaccine will be ready by the 2020 .

this is such a great news you have shared on your blog ,,,looking for more from you

ben thomas
ben thomas
1 month ago

good news now i am happy finally a good solution come. Humans will surely overcome this pandemic. Hopefully a better future will come soon. Lets wait

dabafg
dabafg
1 month ago

Finally, this is what i was hoping for to see while 2020 is still on.

benjhamin
1 month ago

Excelente post sobre este posible fármaco para combatir Covid 19 cosas de este tipo se necesitan en estos momentos así que graciasp or tu aporte amigo espero puedan alvar muchas vidas.

Stan Lee
Stan Lee
1 month ago

We hope that with the favor of God, the vaccine against covid 19 can finally be obtained, this pandemic has already claimed the lives of many people, and we need it not to continue advancing further.

heri nino
heri nino
1 month ago

excellent truthful and accurate information hopefully you can get a drug quickly as scientists say it would be the best for humanity

Adriana nava
Adriana nava
1 month ago

Excellent news, it is the most positive and good thing that I have read these days, we already need an urgent cure against this disease that has affected both the population and the entire world, I thank God for putting professionals in this cure for everyone

ytrnava
ytrnava
1 month ago

Anyone with the exact dates of the vaccine becoming public available?

great article tho!

leroy huerta
1 month ago

excellent blog without a doubt the information given here is very detailed and very useful, it is very good to know how everything is going with respect to this virus, thanks for this contribution I will undoubtedly share it, this information is very useful

bryan lowe
bryan lowe
1 month ago

excellent advice, I will definitely follow them! It shows that you have knowledge on the subject and you know what you do and say … I follow you! I hope to see more content like this on your channel!

cisdelvalle
cisdelvalle
1 month ago

This is very interesting and hopeful to know that it is possible to fight against this tragic disease which has devastated the world really a informative article about Covid-19, I have learnt lots of thing from this. Hope people will know more from this article, I will share and tell about this what I have learnt. Keep up the good work scientists and researchers and all other persons working tirelessly to deliver a cure,we are praying for a breakthrough

sunil
sunil
1 month ago

so great article and so informative
deeply explained with all aspects covered and glad thta i read this article

ANTHONY NANDEIBAM
ANTHONY NANDEIBAM
1 month ago

While the researchers believe further studies are needed to test the drug against COVID-19, they believe the two binding sites on Mpro look promising for Ebselen to be a new drug lead.The main protease is one of many proteins in the virus that could be targeted with existing, repurposed drugs, and there are thousands of compounds to be considered.

jesica simpson
jesica simpson
1 month ago

seems like brilliant news to me. This pandemic has guaranteed numerous human lives, and the way that a medication that can assist with keeping it from spreading has just been found is generally excellent for everybody. Congrats from that gathering of researchers. Great job

Rosa perry
Rosa perry
1 month ago

That’s good news,I am getting after a long time as during this pandemic of covid-19,we are listening only bad news about lots of cases of covid.I hope this drug will help everyone to cure fastly.

cathyd
cathyd
1 month ago

Thank you for this very interesting and informative post. At least three pharmaceutical companies, as well as teams of researchers around the world, have been working on different approaches to producing an effective vaccine. However, the coronavirus is still scary and while we may not have control over everything, there are evidence-based things you can do to help yourself.

Cornell D Johnson
Cornell D Johnson
1 month ago

It is actually great new, I’m happy to hear that candidates try t each vaccine for this horrible disease. Which is a noble work for them, they must be awarded when they find the right cure. Thanks for this post that contains fruitful and useful information.

palma 1
palma 1
1 month ago

Very interesting article and worth to read. With countries especially the west and USA not following to the scientific way of addressing the pandemic, Covid 19 infested be widespread now !

Jose David
Jose David
1 month ago

This is good news, we have already suffered enough thanks to this virus, let’s hope in God that all these discoveries lead to a 100% cure and without any sequential effect, thanks for the blog and the news;)

rayen
rayen
1 month ago

It’s high time a drug is introduced. Lives have stood still and most middle income families have been affected. I can’t wait for a time when we will be free of this virus. I hope this potential drug passes the tests because we are living in fear and its just so sad.

rayen
rayen
1 month ago

Excellent post about this possible drug to combat Covid 19, it is very interesting and hopeful to know that it is possible to fight against this tragic disease which has devastated the world, I hope that everything will be solved soon and that this medication will be of great help, Thank you very much for sharing it!