1. Refer to the given figure of pituitary gland and select the correct options for the question that follows.
What will be the effect if part C is been removed?
(a) Oxytocin and ADH will not be synthesized.
(b) Oxytocin and ADH will be synthesized but could not be stored.
(c) Only synthesis of oxytocin will occur.
(d) Only synthesis of ADH will occur.
2. Select the correct matching of a hormone, its source and function.
3. A patient of diabetes mellitus excretes glucose in urine even when he is kept on a carbohydrate free diet. It is because
(a) fats are catabolised in adipose tissues to form glucose
(b) amino acids are catabolised in kidney to form glucose
(c) amino acids are discharged in blood stream from liver
(d) glycogen from muscles is released in blood stream.
4. The given diagram represents the mechanism of action for two categories of hormones. Which of the following options correctly identifies the labels A to I?
6. Identify from the following, a hormone produced by the pituitary gland in both males and females but functional only in females.
(d) Somatotropic hormone
7. What is correct to say about the hormone action in humans?
(a) Glucagon is secreted by beta-cells of islets of Langerhans and stimulates glycogenolysis.
(b) Secretion of thymosin is stimulated with aging.
(c) In females, FSH first binds with specific receptors on ovarian cell membrane.
(d) FSH stimulates the secretion of estrogen and progesterone.
8. Which one of the following is not the function of insulin?
(a) Increases the permeability of cell membrane to glucose
(b) Increases the oxidation of glucose in the cells
(c) Initiates the conversion of glycogen to glucose
(d) Initiates the formation of hepatic glycogen from excess of glucose
9. Match Column-I with Column-ll and select the correct option from the codes given below.
A. ANF (i) Regulates blood calcium levels
B. MSH (ii) Decreases blood pressure
C. GIP (iii) Pigmentation
D. TCT (iv) Inhibits gastric secretion
(a) A-(iv), B-(i), C-(ii), D-(iii)
(b) A-(ii), B-(i), C-(iv), D-(iii)
(c) A-(iv), B-(i), C-(iii), D-(ii)
(d) A-(ii), B-(iii), C-(iv), D-(i)
10. Estrogen and testosterone are steroid hormones, and most likely bind to
(a) membrane ion channels
(b) enzyme-linked membrane receptors
(c) G-protein coupled membrane receptors
(d) cytoplasmic receptors.
11. Prostaglandins have no role in
(a) inflammatory and allergic reactions
(b) blood clotting
(c) smooth muscle contraction
(d) conduction of nerve impulses.
12. A man is admitted to a hospital. He is suffering from an abnormally low body temperature, loss of appetite and extreme thirst. His brain scan would probably show a tumour in
(c) medulla oblongata
13. In the homeostatic control of blood sugar level, which organs function respectively as modulator and effector?
(a) Liver and islets of Langerhans
(b) Hypothalamus and liver
(c) Hypothalamus and islets of Langerhans
(d) Islets of Langerhans and hypothalamus
14. Rapid increase in the blood sugar level of a patient can be immediately reduced by
(a) injecting insulin intravenously
(b) injecting insulin intramuscularly
(c) administering glucagon intravenously
(d) consuming large quantities of insulin tablets.
15. Which of the following endocrine gland stores its secretions in the extracellular space before discharging it into the blood?
(a) Pancreas (b) Adrenal
(c) Testis (d) Thyroid
True or False
16. T, is more active and several times more potent than Tr
17. Deficiency of iodine leads to thyroid enlargement.
18. Excess of PTH causes demineralisation and softening of bones resulting in osteoporosis.
19. Cortisol is used for treatment of allergy as it causes production of lymphocytes to suppress allergy.
20. Adrenal medulla forms about 75% of adrenal gland and is simply an extension of the sympathetic nervous system.
21. The dairy owners inject synthetic oxytocin or pitocin, into their cows and buffaloes, to increase milk yield.
22. Calcitriol is the active form of calciferol.
23. Leukotrienes (LTs) are mediators of allergic as well as inflammatory responses.
24. All hormones regulate gene expression or chromosome function by the interaction of hormone-receptor complex with the genome.
25. The pituitary hormones oxytocin and ADH are synthesized in the hypothalamus.
Match Column-I with Column-ll and select the correct option from codes given below.
A. Cortisol (i) Adrenal medulla
B. Glucagon (ii) PTH
C. Chromaffin cells (iii) Stress hormone
D. Oxyphil cells (iv) Glucocorticoids
E. Zona fasciculata (v) Emergency hormone
F. Epinephrine (vi) Mineralocorticoids
G. Zona glomerulosa (vii) Anti-insulin
27. Match Column-I with Column-ll and select correct options from codes given below. There can be more than one match for items in Column-1.
A.Pancreas (i) Antidiuretic effect
B.Pitressin (ii) D cells
C.Kidney (iii) Cushing’s syndrome
D.Parathyroid (iv) Erythropoietin
E.Small intestine (v) Collip’s hormone
F.Adrenal cortex (vi) GIP
G.Thyroid (vii) C cells
(xii) Pressor effect
(xiii) F cells
(xiv) Conn’s syndrome
Passage Based Questions
28.(A) Complete the given passage with appropriate words or phrases.
(i) is secreted by the (ii) of brain, (iii) cells of islets of Langerhans in the pancreas and (iv) cells of digestive tract. It inhibits secretion of (v) from anterior lobe of pituitary.
(B) Read the passage and correct the errors, wherever present.
Cushing’s syndrome is caused by excess of mineralocorticoids and sexcorticoids. It is also caused by tumour of adrenal cortex. Its symptoms include high blood sugar, high K+ plasma, high Na+ plasma and increased urinary Na–.
Assertion & Reason
In each of the following questions, a statement of Assertion is given and a corresponding statement of Reason is given just below it. Of the statements, mark the correct answer as :
(a) if both A and R are true and R is the correct explanation of A
(b) if both A and R are true but R is not the correct explanation of A
(c) if A is true but R is false
(d) if both A and R are false.
29. Assertion : Simmond’s disease is characterised by premature ageing and dry, wrinked skin.
Reason : It is caused due to atrophy of anterior lobe of pituitary gland.
30. Assertion: Melatonin concentration in the blood rises in the evening through the night, and drops to a low around noon.
Reason : It is believed to act as a ‘biological dock’ and produce circadian rhythms.
31. Assertion : Insulin is an anabolic hormone.
Reason : It promotes protein synthesis from amino acids.
32. Assertion : Pregnant women generally experience increase in shoe size.
Reason : It is due to the secretion of relaxin by the placenta, during pregnancy.
33. Assertion : Excessive development of male mammary glands is called gynaecomastia.
Reason : Deficiency of testosterone in later life may cause gynaecomastia.
34. Assertion : Sexual pseudoprecocity in girls is due to tumours of ovaries and adrenal glands resulting in excess secretion of oestrogen.
Reason : It is characterised by breast formation, early appearance of pubic hair, maturation and discharge of ova.
35. Assertion : Pineal gland starts to calcify at the time of puberty resulting in brain sand.
Reason : Brain sand is believed to be indicative of increased secretory activity.
36. Assertion : Thymus gland weighs about 10-15 gm at birth, continues to grow till puberty-becoming 30-40 gm and then undergoes atrophy at mid-adult life, weighing only about 10gm.
Reason : Hassall’s corpuscles in the thymus are responsible for its atrophy.
37. Assertion : Prostaglandins (PGs) cause contraction of smooth muscles.
Reason : They cause contraction of uterine muscles to facilitate ascending of sperms into fallopian tubes.
38. Assertion : A hormone which stimulates pituitary to secrete its hormone is called trophic hormone.
Reason: The thyrotrophic hormone stimulates pituitary to secrete its hormone.
Figure Based Questions
39.In the given figure, showing role of cAMP in hormone action, identify 1 – 8
40. State the level of amplification at the following stages.
(i) At 2
(ii) At 4
(iii) At 6
(iv) At 8
I. (b) 2. (b) 3. (a) 4. (b) 5. (b)
6. (c) 7. (c) 8. (c) 9. (d) 10. (d)
II. (d) 12. (b) 13. (c) 14. (a) 15. (d)
16. False. T3 is more active and potent than T,.
17. True 18. True
19. False. It causes suppression or inhibition of lymphocytes.
20. False. It forms 25% of the adrenal gland.
22. False. It is the cholecalciferol or vitamin D3.
24. False. It is the steroid hormones through intracellular receptors.
26. A-(iii), B-(vii), C-(i), D-(ii), E-(iv), F-(v), G-(vi)
27. A-(ii, xiii), B-(i, xii),C-(iv, ix), D-(v, xi), E-(vi, x), F-(iii, xiv), G-(vii, viii)
28. (A)(i) SS or Somatostatin, (ii) Hypothalamus, (iii) Delta
cells, (iv) Argentaffin, (v) Somatotropin.
(B) Cushing’s syndrome Addison’s disease is caused by excels deficiency of mineralocorticoids and sexcortieoids glucocorticoids. It is also caused by tumour destruction of adrenal cortex. Its symptoms include high low blood sugar, high K* plasma, htgh low Na+ plasma and increased urinary Na+.
29. (a) 30. (a) 31. (a) 32. (a) 33. (b) 34. (c) 35. (b) 36. (c) 37. (a) 38. (d)
(1) Inactive protein kinase A;
(2) Active protein kinase A;
(3) – Inactive phosphorylase kinase;
(4) – Active phosphorylase kinase;
(5) – inactive glycogen phosphorylase;
(6) – Active glycogen phosphorylase; (7) – Glycogen;
(8) – Glucose 1-phosphate.
40. (i) 102 (ii) 104 (iii) 106 (iv) 108.