Applied Genetics MCQs Part II

1) Hydrophobia is caused by a
a) Bacterium
b) Fungus
c) Virus
d) Protozoa

2) Which of the following diseases is caused by a virus?
a) Malaria
b) Influenza
c) Diphtheria
d) Syphilis

3) Which of these are viral diseases?
a) Influenza, mumps, and measles
b) Small pox and chicken pox
c) Polio and Hydrophobia
d) All the above

4) Which of the following diseases is caused by a virus?
a) Tuberculosis
b) Typhoid
c) Polio
d) Diphtheria

5) Chicken pox is caused by
a) Bacteria
b) Bacteriophage
c) Varicella virus
d) Pox virus

6) Which of the following characters justify the living nature of viruses?
a) Multiplicity
b) Mutability
c) Capability of protein synthesis
d) All

7) The best evidence which supports the living nature of viruses is that the viruses
a) are made up of common chemicals
b) duplicate themselves
c) Cause diseases
d) Penetrate a cell membrane

8) Viruses are obligate intracellular parasites
a) Cell wall
b) Reserve food
c) Amino acids and ribosomes
d) None of the above

9) Which of the following is not correct regarding viruses-?
a) they are made up of nucleic acids and proteins
b) They can multiply in host cytoplasm
c) They can grow in dilute sugary solution

10) Which of the following characteristics of living organisms are absent from

a) Mutation
b) Replication
c) Production of energy
d) All

11) Viruses are considered to be
a) Living organisms
b) Non living objects
c) A transitional group between non living and living
d) Living organisms which have lost the power of multiplication

12) The latest view about the the origin of viruses is that:
a) These have arisen from nucleic acid and protein found in the primitive soup
b) These arose from bacteria as a result of the loss of cell wall, ribosome etc
c) These arose from some bacteria which had developed a nucleus only
d) These are modified plasmids which are in fact the fragments of the nucleic acids of the host

13) Viral vaccines contain
a) live viruses
b) Live attenuated viruses
c) Extracts of pathogenic viruses
d) All of these

14) Which of the following was used by Hershey and Chase to prove that DNA is
the chemical basis of heredity?

a) Dahlia mosaic virus
c) Tobacco mosaic virus
d) Cauliflower mosaic virus

15) Bacteriophages are of interest to scientists because
a) these contain DNA
b) these kill bacteria
c) these are small
d) these bring about transduction

16) A virus can be made radioactive by

17) A substance which kills viruses is called a
a) Germicide
b) Antibiotic
c) Virucide
d) Virion

18) The antiviral substance produced by animals (or many vertebrates) in response
to viral infection, and helps to resist the multiplication of viruses, is known as

a) Virion
b) Interferon
c) Antivirin
d) Antigen

19) Tailed bacteriophages are
a) Motile on surface of bacteria
b) Non motile
c) Actively motile in water
d) Motile on surface of plant leaves

20) Antibiotics have no effect on viruses because
a) They kill all bacteria which act as the hosts of viruses
b) Viruses are too small in size for antibiotics to act upon them
c) Viruses show no metabolism of their own
d) Viruses produce a thick covering and encyst themselves as endospores.

21) Viroids differ from viruses in being
a) naked RNA molecules only
b) naked DNA molecules only
c) naked DNA packaged with the viral genome
d) Satellite RNA packaged with the viral genome

22) Virioids have
a) Single stranded RNA not enclosed by protein coat
b) Single stranded DNA nor enclosed byy protein coat
c) Double stranded DNA enclosed by protein coat
d) Double stranded RNA enclosed by protein coat

23) Which of the following viruses is devoid of a protein coat with their entire
body constituted by RNA only?

a) Tobacco mosaic virus (TMV)
b) Potato spindle tuber virus (PSTV)
c) Polyoma virus
d) Mumps virus

24) The smallest known agent of a disease is a
a) Virus
b) Virioid
c) Bacteria
d) Mycoplasma

25) A naked RNA particle causing symptoms like that of a virus disease is
known as

a) viroid
b) viron
c) Virus
d) None of these

26) On the basis of the host attacked, viruses are classified into
a) two types
b) three types
c) four types
d) five types

27) The virus responsible for AIDS is an example of a/an
a) Adeno virus
b) Mosaic virus
c) T-even virus
d) Retrovirus

28) Interferon is a natural product of the animal cell. This protects
a) bacteria against a variety of viruses
b) Animal cells against the attack of a specific virus
c) Human cells against a variety of viruses
d) None of the above.

29) In which one of the following pairs of disease are both caused by viruses?
a) Tetanus and typhoid
b) Syphilis and AIDS
c) Whooping cough and sleeping sickness
d) Measles and rabies

30) Pulse Polio Immunisation is being carried out with the aim of
a) treating polio
b) preventing deformitieis due to polio
c) containing polio
d) eradicating polio

31) The filterable property of tobacco mosaic virus (TMV) was shown by
a) Ivanowsky
b) Beijerinck
c) Stanley
d) Winogradsky

32) DNA is transcribed over some viral RNA using the enzyme
a) DNA polymerase
b) Reverse transcriptase
c) Endonuclease
d) Ligase

33) Cyanophages attack
a) cyanobacteria
b) bacteria
c) fungi
d) Lichens

34) Interferons are useful in controlling
a) Cancer
b) Tuberculosis
c) Blood pressure
d) Malaria

35) Which one of the following statements is correct?
a) Viruses are obligate parasites
b) All fungi are pathogenic
c) All algae are eukaryotic
d) Bacteria are always harmful to mankind

36) Retroviruses are implicated as a cause for cancer in humans because they
a) they may carry v-oncogenes in their genome
b) carry single stranded RNA as their genetic material
c) carry genes for reverse transcriptase
d) may carry cellular proto-oncogenes in their genome

37) Which one of the following enzymes is present in the bacteriophage?
a) Protease
b) Lysozyme
c) Succinic Dehydrogenase
d) Urease

38) Interferons are:
a) antiviral proteins
b) complex proteins
c) anti bacterial proteins
d) anti cancer proteins.

39) The concept of operon was proposed by
a) Jacob and Monod
b) Watson and Crick
c) Khorana
d) Kornberg

40) Which type of prokaryotic cell would be more successful as judged by its growth potential?
a) one that is able to express all its genes all the time
b) one that is unable to express any of its genes any of the time
c) one that expresses some of its genes some of the time
d) one that divides only when all types of amino acids and sugars are present in the medium

41) Which one of the following is the correct sequence of genes within an

a) Regulator, promoter, operator, structural
b) Regulator, operator, promoter, structural
c) Structural. operator, regulator, promoter
d) Promoter, operator, structural, regulator

42) The segment of a DNA molecule determining the amino acid sequence of
a protein is known as the

a) Operator gene
b) Regulator gene
c) Structural gene
d) Modifier gene

43) The gene that codes for a repressor protein is called a
a) Promoter
b) Regulator
c) Operator
d) Structural gene

44) A short sequence of DNA where the repressor binds, preventing RNA polymerase
from attaching to the promoter is called the

a) Regulator
b) Operator
c) Promoter
d) None

45) In the operon model, RNA polymerase binds to the
a) structural gene
b) regulator gene
c) operator gene
d) promoter gene

46) Lac operon is related to
a) synthesis of the enzymes of lactose catabolism
b) synthesis of the enzymes of lactose anabolism
c) synthesis of lac by insects
d) degradation of lac in the body of lac insects

47) Wild type E. coli are growing in a normal medium with glucose. They are transferred to a medium
containing only lactose as the sugar. Which of the following changes takes

a) The lac operon is repressed
b) All operons are induced
c) The E. coli cell stops dividing
d) The lac operon is induced

48) The lac operon is an example of a/an
a) arabinose operon
b) inducible operon
c) repressible operon
d) overlapping genes

49) An environmental agent that triggers transcription from an operon
is a/ an

a) Derepressor
b) Inducer
c) Regulator
d) Controlling element

50) In E. coli, the lac operon is induced by
a) Lactose
b) I-gene
c) Promoter gene

51) When lactose is present:
a) the repressor is able to bind to the operator
b) the repressor is unable to bind to the operator
c) transcription of lac Y, lac Z and lac A genes occurs
d) both b and c are correct

52) A gene which synthesises a repressor protein is a/an
a) Operator gene
b) Promoter gene
c) Structural gene
d) Regulator gene

53) How many structural genes are present in the tryptophan operon
of Escherichia coli?

a) Three
b) Five
c) Seven
d) One only

54) When tryptophan is present:
a) transcription of structural genes occurs
b) the repressor is able to bind to the operator
c) the repressor is unable to bind to the operator
d) both (b) and (c) are correct

55) A repressor is the product of the
a) Operator gene
b) Structural gene
c) Promoter gene
d) Regulator gene

56) During genetic induction, a repressor is synthesised from the
a) regulator gene
b) structural gene
c) operator gene
d) regulator gene

57) “Gene-Battery model” of gene expression in eukaryotes
was proposed by

a) Jacob and Monod
b) Britten and Davidson
c) Beadle and Tatum
d) Nirenberg

58) In split genes, the coding sequences are called
a) Cistrons
b) Operons
c) Exons
d) Introns

59) RNA processing is:
a) the same as transcription
b) an event that occurs after RNA is transcribed
c) the rejection of old, worn-out RNA
d) both (b) and (c) are correct

60) The concept of split gene is that the
a) DNA in a gene can be split by deoxyribonuclease
b) Secondary constrictions on the chromosomes give a split appearance to genes
c) Adjacent genes are separated from each other by spacers
d) Coding sequences in many eukaryotic genes are often separated by non-coding sequences

61) Primary RNA products transcribed by the eukaryotic gene contain
regions complementary to

a) Exons
b) Introns
c) Both
d) None

62) Split genes are made of
a) Cistrons and introns
b) Exons and cistrons
c) Exons and introns
d) Recons and mutons

63) Genes that are involved in turning on or off the transcription
of a set of structural genes are called

a) Polymorphic genes
b) Redundant genes
c) Regulator genes
d) Operator genes

64) The immediate product of transcription in eukaryotes will be
a) Hn-RNA
b) m-RNA
c) C-DNA
d) Sn-RNA

65) Introns are the
a) coding part of mRNA
b) non-coding part of mRNA
c) sequence of essential amino acids required for protein synthesis
d) gene preset on DNA

66) In the inducible operon concept of a gene a regulator gene produces a
a) regulator
b) inducer
c) repressor
d) inhibitor

67) The origin of life is also called
a) biogenesis
b) protobiogenesis
c) biopoesis
d) Abiogenesis

68) Which of the following is supposed to have been present in the primitive earth?
a) Ammonia and helium
b) Water vapour
c) Oxygen
d) Hydrogen and methane

69) Which of the following evolved first?
a) Photosynthesis
b) Respiration
c) Transpiration
d) Formation of macromolecules

70) The theory of spontaneous generation was criticized by
a) Redi
b) Pasteur
c) Oparin
d) Urey and Miller

71) Catastrophes according to Cuvier came periodically and
a) caused new life forms to appear
b) destroyed all life
c) effected evolution
d) any of these

72) A protovirus is
a) a free-living virus
b) a free living nucleus
c) a free-living DNA
d) a free gene

73) Which of the following has a nucleus?
a) Protovirus
c) Protistan
d) Moneran

74) A transgenic crop that is resistant to hornworm larvae is
a) Sunflower
b) Tomato
c) Tobacco
d) Sugarcane

75) Which of these is not correctly matched ?
a) Organochlorine ——– D.D.T
b) Organophosphate———Malathion
c) Carbamate————- Carbryl
d) Pyrethoid————- Atrazine

76) The branch of science related to the improvement of the human race through laws of heredity is
a) Hereditary
b) Genetics
c) Eugenics
d) Euthenics

77) Genetic engineering requires the enzyme
a) Dnase
b) Amylase
c) Restriction endonuclease
d) Lipase

78) A new crop ‘Triticale’ has been evolved by intergeneric hybridization between
a) Rice and maize
b) Wheat and rye
c) Wheat and Aegilops
d) Wheat and rice

79) Humulin is
a) A form of chitin
b) A powerful antibiotic
c) A new digestive enzyme
d) Human insulin

80) Hybridomas are employed for
a) Synthesis of antibiotics
b) Killing cancer cells
c) Synthesis of monoclonal antibodies
d) Production of somatic hybrids

81) Haploid plants can be obtained by culturing
a) Young leaves
b) Endosperm
c) Pollen grains
d) Root tips

82) Genetically engineered bacteria have been used in the commercial production of
a) Thyroxine
b) Testosterone
c) Human insulin
d) Melatonin

83) Which of the following organelles is related with Genetic Engineering?
a) Golgi apparatus
b) Lysosomes
c) Mitochondria
d) Plasmids

84) Restriction endonuclease is employed for cutting
a) A single stranded DNA
b) Double stranded DNA
c) RNA fragment
d) mRNA

85) Restriction enzymes are used in genetic engineering because they
a) Can join DNA fragments
b) Cut DNA at specific base sequence
c) Cut DNA at variable sites
d) Are proteolytic enzymes which degrade harmful proteins.

86) Genetically engineered bacteria are being used in commercial production of
a) Melatonin
b) Testosterone
c) Human insulin
d) Thyroxine

87) Bacterial plasmid contains
a) RNA
b) RNA + protein
c) DNA
d) Photosynthetic structures

88) Plasmids are vectors for gene cloning because they
a) Self replicate in bacterial cells
b) Replicate freely outside bacterial cells
c) Can be multiplied in culture
d) Can be multiplied in laboratories using enzymes

89) The technique of insertion of a desired gene into DNA of plasmid vector is
a) Gene splicing
b) Gene dressing
c) Gene cloning
d) Gene drafting

90) The enzyme required for the polymerase chain reaction (PCR) is
a) RNA polymerase
b) Ribonuclease
c) Taq polymerase
d) Endonuclease

91) A good vector in genetic engineering is
a) Agrobacterium tumefaciens
b) Bacillus thuringiensis
c) Bacillus amyloliquefaciens
d) Salmonella typhimurium

92) An abnormal gene is replaced by a normal gene. This technique is called
a) Gene therapy
b) Cloning
c) Mutation
d) None of the above

93) Introduction of genetically modified food is not desirable because
a) It will affect the economy of developing countries
b) The products are less tasty
c) They are costly
d) There is danger of entry of toxins and viruses in food.

94) Genetic engineering is
a) Making artificial genes
b) Hybridisation of DNA
c) Making artificial limbs and diagnostic instruments
d) Production of alcohol by using microorganisms.

95) A widely used tool in genetic engineering of crop plants is
a) Protoplast fusion
b) Transposon
c) Microinjection
d) Agrobacterium mediation

96) Polymerase chain reaction is useful in
a) DNA synthesis
b) DNA amplification
c) Protein synthesis
d) Amino acid synthesis

97) Electroporation is
a) Making transient pores in cell membrances to introduce gene constructs
b) Fast passage of nutrients through phloem sieve pores by electric stimulation
c) Opening of stomata by artificial light during night
d) Purification of saline water with the help of membrance system

98) A herbicide resistant gene is
a) Ct
b) Mt
c) Bt
d) GST

99) A Vitamin A rich transgenic plant is
a) Flavr Savr Tomato
b) Golden Rice
c) Bt Cotton
d) Vaccinated Potato

100) A plant expressing a gene from another organism is called
a) Transgenic
b) Clone
c) Somaclonal variant
d) Transformed


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